ANALYZING THE ROLE OF ETANERCEPT IN FLS CELL LINE IN TREATMENT OF RHEUMATOID ARTHRITIS

Abstract

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent joint inflammation, leading to pain, swelling, and progressive joint damage. Current treatment options, including nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids, and biologics, often present side effects and high costs, necessitating the exploration of alternative therapies. Drynaria quercifolia, a medicinal fern known for its anti-inflammatory and antioxidant properties, has shown potential in alleviating symptoms associated with RA. This study investigates the bioactive compounds of Drynaria quercifolia and their therapeutic efficacy in modulating inflammatory pathways involved in RA. Phytochemical analysis and in vitro assays were conducted to assess its anti-inflammatory activity, followed by in vivo studies to evaluate its effectiveness in an RA-induced FLS (Fibroblast-Like Synoviocytes) cell line. Preliminary findings suggest that extracts of Drynaria quercifolia exhibit significant inhibition of pro-inflammatory cytokines and oxidative stress markers, indicating its potential as a natural therapeutic agent for RA. Further research is warranted to elucidate its mechanism of action and validate its clinical applicability.